Which method is NOT typically used for achieving sterility in high risk CSPs?

In the context of achieving sterility in high-risk compounded sterile preparations (CSPs), non-sterile water is not an appropriate choice for ensuring sterility. High-risk CSPs are defined as those that contain sterile ingredients but are compounded under conditions that could introduce contamination, and thus require methods that can guarantee the elimination of any microbes or pathogens.

Terminal sterilization, filtration through a 0.2 micron filter, and performing chemical disinfection are all established methods used to achieve sterility. Terminal sterilization typically involves processes like autoclaving or dry heat sterilization, which effectively eliminate all forms of microbial life. Filtration through a 0.2 micron filter is a physical method designed to remove bacteria from solutions, ensuring the final product is free of contamination. Chemical disinfection involves using agents that can effectively kill or inactivate pathogens on surfaces and equipment used in sterile compounding.

In contrast, using non-sterile water introduces potential contamination into the sterile compounding process, undermining the assurance of sterility that high-risk CSPs must adhere to. Therefore, it is critical to utilize only sterile water or other sterile solvents in these preparations to maintain sterility and ensure patient safety.