When performing manipulations of low-risk CSPs, what is permitted?

When performing manipulations of low-risk Compounded Sterile Preparations (CSPs), aseptically opening ampules is permitted because it follows the guidelines for maintaining sterility and aseptic conditions. In the context of low-risk CSPs, the focus is on minimizing contamination during the preparation process. Aseptically opening an ampule ensures that the contents remain sterile since it requires the use of sterile technique to prevent any microbial contamination.

Maintaining aseptic technique during this step is essential, as it involves using appropriate barriers and ensuring a clean environment, which enhances the safety and efficacy of the compounded medication. This action is a standard practice in sterile compounding since ampules are designed to provide a sterile liquid; how they are opened can influence the sterility of what's inside.

For the other choices, they are not aligned with low-risk conditions due to the increased risk of contamination they introduce. Non-sterile measurements, using open containers, and handling multiple sterile containers simultaneously can compromise the sterile integrity of the preparations, which is why they are not permitted in low-risk compounding situations.