What must be true about filters used for sterilizing CSP solutions?

For filters used in sterilizing compounded sterile preparations (CSP) solutions, it is essential that they are pyrogen-free. This is because pyrogens, which are typically bacterial endotoxins, can cause fever and other adverse reactions when introduced into the bloodstream or tissues. Ensuring that filters are free of pyrogens helps to guarantee the safety and efficacy of the sterile preparation.

While other attributes, such as being disposable or having specific pore sizes, are important considerations for filters used in sterile compounding, they do not hold the same critical significance when it comes to the pyrogenicity of the filter material. Pore size is crucial for ensuring that the filter can adequately remove bacteria, but not all filters will be pyrogen-free, nor are they required to be biodegradable. Thus, the property of being pyrogen-free is paramount for maintaining patient safety in sterile preparations.