What is the typical beyond-use date for a needle-punctured multiple-dose container?

A typical beyond-use date for a needle-punctured multiple-dose container is 28 days. This guideline is based on stability studies and ensures that the medication remains effective and safe for use after the container has been accessed. The 28-day period helps to minimize the risk of contamination and degradation of the drug, which can occur once the container is punctured and exposed to environmental factors.

In the case of multiple-dose containers, the 28-day beyond-use date is a standard practice that healthcare professionals adhere to in order to maintain quality and safety in compounded sterile preparations. This timeframe is generally accepted across various compounding references, ensuring consistency in practice and patient safety.