What is the osmolality threshold for a drug administered via a central line?

The correct choice relates to the safe administration of hypertonic solutions through central venous access. Central lines are designed to handle higher osmolality solutions compared to peripheral lines because they can accommodate the dilution of these solutions into the larger volume of blood flowing through the central circulation.

Administering solutions with an osmolality greater than or equal to 900 mOsm/L through a central line minimizes the risk of irritation and damage to the endothelium of smaller veins, which is particularly important in preventing phlebitis and complications from extravasation. This threshold is set to ensure patient safety and maintain vascular integrity.

Using a solution with an osmolality lower than this threshold is typically acceptable for peripheral administration, but central lines provide a more robust route for solutions that exceed this level. Therefore, the choice of an osmolality threshold greater than or equal to 900 mOsm/L for central line administration aligns with established guidelines in sterile compounding practices to protect patient safety while delivering necessary therapies.