At what temperature is depyrogenation achieved using dry heat?

Depyrogenation using dry heat is effectively achieved at a temperature of 250 degrees Celsius. This temperature is high enough to ensure that pyrogens, which are heat-stable substances often produced by microorganisms, are destroyed. The process involves exposing the items to this temperature for a specific duration to ensure that all pyrogens are eliminated, thereby ensuring the sterility and safety of the compounded sterile products.

The choice of 250 degrees Celsius aligns with scientific guidelines and practices established for depyrogenation in a sterile compounding environment. It is recognized as a standard temperature that balances efficacy with safety, ensuring that materials remain intact while effectively achieving the desired sterilization. Higher temperatures might not provide additional benefits for depyrogenation and could risk damaging certain materials, while lower temperatures would not be sufficient to achieve the required level of efficacy in pyrogen removal.